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Gene Therapy Clinical Trial Databases

  Wiley database on Gene Therapy Trials Worldwide
The Journal of Gene Medicine clinical trial site presenting charts and tables showing the number of approved, ongoing or completed clinical trials worldwide. Data is available for: Continents and countries where trials are being performed; Indications addressed; Vectors used; Gene types transferred; Phases of clinical trials; Number of trial approved/initiated 1989-2007.
A searchable database is also present with detailed information on individual trials. The data are compiled and are regularly updated from official agency sources (RAC, GTAC etc..), the published literature, presentations at conferences and from information kindly provided by investigators or trial sponsors themselves. Beware that information on some trials is incomplete as some countries regulatory agencies simply do not disclose any information.
See also: Gene therapy clinical trials worldwide to 2012 - an update. J. Gene Med. 2013 Feb;15(2):65-77.
  ClinicalTrials.gov database on clinical trials performed in the US and worldwide
The U.S. National Institutes of Health, through its National Library of Medicine, has developed ClinicalTrials.gov to provide patients, family members and members of the public current information about clinical research studies. The database is a registry of federally and privately supported clinical trials conducted in the United States and around the world. ClinicalTrials.gov gives you information about a trial's purpose, who may participate, locations, and phone numbers for more details.
>> Overview of gene therapy trials recently received in the last 30 days.
  International Standard Randomised Controlled Trial Number Register
The ISRCTN Register is a register containing a basic set of data items on clinical trials that have been assigned an ISRCTN. Records are never removed from the ISRCTN Register (except in cases of duplications), which ensures that basic information about trials registered with an ISRCTN will always be available. The ISRCTN Register complies with requirements set out by the World Health Organization (WHO) International Clinical Trials Registry Platform (ICTRP) and the International Committee of Medical Journal Editors (ICMJE) guidelines, and complies with the WHO 20-item Trial Registration Data Set.
  Selected Gene Transfer and Therapy References database
The database is managed by Clinigene. The aim of this webpage is to provide database of selected references in the field of Gene Transfer and Therapy, addressing technological issues, applications, ethics and regulation from four main databases: Quality/Efficacy; Safety (pre-clinical); Adverse events (clinical); Important clinical trials. The database is open to the public and it is by no means intended to be either complete or comprehensive.
  Published Human Gene Therapy Clinical Trials database
The database is maintained by Clinigene. The aim of this website is to provide a complete database of all published clinical gene therapy trials carried out worldwide. At this point in time the database is nearing completion and is open to the public.

  GeMCRIS - NIH Genetic Modification Clinical Research Information
GeMCRIS allows users to access an array of information about human gene transfer trials registered with the NIH, including medical conditions under study, institutions where trials are being conducted, investigators carrying out these trials, gene products being used, route of gene product delivery, and summaries of study protocols.
  US National Cancer Institute - Cancer Trials
The database includes most clinical trials sponsored by NCI. The registry contains more than 5,000 abstracts of clinical trial protocols that are open/active and approved for patient accrual (accepting patients), including trials for cancer treatment, genetics, diagnosis, supportive care, screening, and prevention. In addition, the registry contains more than 16,000 abstracts of clinical trial protocols that have been completed or are closed to patient accrual.

 
  EU Clinical Trials Register
The EU Clinical Trials Register website allows you to search for information on clinical trials in European Union (EU) member states and the European Economic Area (EEA) and clinical trials which are conducted outside the EU/EEA if they form part of a paediatric investigation plan. The information on the website is collected and entered by national medicine regulatory authorities or by the addressee of a PIP decision for trials conducted outside the European Union. They are required by European Union law to enter details of clinical trials into a database called EudraCT. The information stored in this database is now being made publicly available through a new website, the EU Clinical Trials Register. Information on the website dates from May 2004.
  EU Deliberate release database on clinical trials (JRC)
The site is managed by the Joint Research Centre of the European Commission on behalf of the Directorate General for the Environment. The purpose of the site is to manage all the information flow to and from the public regarding deliberate field trials under EU Directive 2001/18/EC, including gene therapy. Be aware that in some EU member states gene therapy trials fall under the EU contained use directive and are not listed in this database.
  Belgium: Clinical data on approved gene therapy clinical trials
As of July 2007, 19 gene therapy protocols have been approved in Belgium (Table 1). Sixteen of these protocols were multicenter. All trials were carried out in academic hospitals and approved for "contained uses of genetically modified micro-organisms". Five protocols were also approved for "deliberate release of genetically modified micro-organisms for research and development purposes". The above database illustrates the most relevant clinical data of the authorised trials. Most protocols aimed at cancer therapy. Thirteen of them used viral vectors.
  France: Gene Therapy Clinical Trials database
Database on clinical gene therapy trials is available only in French (restricted access).
  Netherlands: Clinical Trials Register
Information on clinical trials in the Netherlands. The Trail Register is part of the Dutch Cochrane Centre.
  Netherlands: Gene Therapy Clinical Trials database
Information on clinical gene therapy protocols is available from this governmental site which provides information only in Dutch.
See also: Gene therapy in The Netherlands: highlights from the Low Countries. J. Gene Med. 2007 Oct;9(10):895-903.

  Australia New Zealand Clinical Trials Registry (ANZCTR)
The ANZCTR is an online register of clinical trials being undertaken in Australia and New Zealand. The ANZCTR includes trials from the full spectrum of therapeutic areas trials of pharmaceuticals, surgical procedures, preventive measures, lifestyle, devices, treatment and rehabilitation strategies and complementary therapies. It has coverage all clinical trials involving Australian/New Zealand researchers or participants. Trials that do not involve Australian/New Zealand researchers or participants will be accepted if there is not a more appropriate national registry with which they should be lodged.



Information Databases

Databases of clinical gene therapy trials are gathered on this site. The databases are listed as follows:
Worldwide
US
Europe
Other



Participate in Trial

Are you a patient and considering to participate in a clinical gene therapy trial? Your doctor may be an excellent resource to help identify clinical trials for a particular disease. There are a number of online resources that can also assist in locating clinical trials that are accepting patients:
ClinicalTrials.gov
Cancer.gov
CenterWatch

When looking for a clinical trial, remember to make sure the trial is appropriate for the disease. Most trials also specify an age range for the participants. Additional eligibility requirements must also be met, but these will vary depending on the individual study. Contact the health professionals if they are not listed. It is always best to discuss these issues before you travel to gene therapy center. More clinical trial information.


Be aware that Gene Therapy Net is not intended to replace or constitute the giving of medical treatments or advice.