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Latest Articles on Gene Therapy
Overview of latest articles and publications on gene therapy in PubMed, including Human Gene Therapy, Journal of Molecular Medicine and Journal of Gene Medicine. PubMed is a service of the US National Library of Medicine that includes over 18 million citations from MEDLINE and other life science journals.
- CLU polymorphisms and plasma clusterin levels in patients with multiple sclerosis: association with disability scores, progression rate and fingolimod therapy Mon, 28 Apr 2025 06:00:00 -0400
OBJECTIVES: Multiple sclerosis (MS) is a chronic, demyelinating disorder of the central nervous system that is widely accepted to result from a complex interplay of genetic and environmental factors. The involvement of clusterin in neurodegenerative and autoimmune diseases has been highlighted, but its role in MS remains unclear. This study aimed to investigate the association of four single nucleotide polymorphisms (SNPs) in the clusterin gene (CLU) with MS susceptibility. - Rapid screening system to identify unspecific peroxygenase activity Mon, 28 Apr 2025 06:00:00 -0400
Unspecific peroxygenases (UPO, EC 1.11.2.1) are a valuable tool for the biocatalytic synthesis of specialty chemicals such as pharmaceutical metabolites. However, the search for new UPOs that are recombinantly expressible can be tedious and dependent on expensive equipment, especially when a large number of clones has to be examined. In this study, we present a simple agar plate-based method for the screening of active, secreted UPOs heterologously expressed in Saccharomyces cerevisiae. This... - Defect-Rich MoO3-X@CuO2 Nanosheets Mediated Ultrasound-Enhanced Cuproptosis Antibacterial Activity and M2 Macrophage Reprogramming for Optimizing Diabetic Wound Repairment Mon, 28 Apr 2025 06:00:00 -0400
Diabetic wounds are often plagued by persistent bacterial infections, which exacerbate inflammation and impair healing processes such as collagen deposition and fibroblast migration. Conventional antibiotic therapies frequently prove ineffective and can even hinder wound repair. To address these challenges, biodegradable MoO(3-x)@CuO(2) ion disruptors (MCO IDs) that for comprehensive diabetic wound treatment is developed. The MCO IDs generate a burst of multimodal reactive oxygen species (ROS)... - Effect of NME2 and SAMHD1 genetic polymorphisms involved in Ara-C metabolism on the response to induction chemotherapy in adult acute myeloid leukemia Sun, 27 Apr 2025 06:00:00 -0400
CONCLUSION: CR, DFS, and OS were not significantly associated to SAMHD1 rs28372906 and NME2 rs3744660 polymorphisms. - Mechanistic insights into proteasome inhibitor MG132 induced apoptosis in melanoma A375 cells Sun, 27 Apr 2025 06:00:00 -0400
Despite advancements in melanoma therapy, the prognosis remains unfavorable for many patients. The proteasome inhibitor MG132 has shown therapeutic potential through pathway regulation, yet its precise mechanisms in melanoma require systematic elucidation. Using A375 melanoma cells, we conducted multi-modal investigations combining cytotoxicity assessment (CCK8), migration analysis (wound healing), apoptosis quantification (flow cytometry), and proteomic profiling (western blot) to dissect... - The role of Wnt/beta-catenin signaling in lung cancer progression and therapy: a comprehensive review Sun, 27 Apr 2025 06:00:00 -0400
Most instances of lung cancer (LC), which is the primary cause of cancer-related death worldwide, are non-small-cell lung cancer (NSCLC). Genetic predispositions, environmental exposures, and smoking are risk factors that lead to the development of LC, and the ineffectiveness of existing treatments emphasizes the need for innovative approaches to therapy. Through its regulation of cell proliferation, apoptosis, epithelial-to-mesenchymal transition (EMT), and cancer stem cell maintenance, the... - Lactate-coated polyurea-siRNA dendriplex: a gene therapy-directed and metabolism-based strategy to impair glioblastoma (GBM) Sun, 27 Apr 2025 06:00:00 -0400
Glioblastoma (GBM) is a highly lethal disease with limited treatment options due to its infiltrative nature and the lack of efficient therapy able to cross the protective blood-brain barrier (BBB). GBMs are metabolically characterized by increased glycolysis and glutamine dependence. This study explores a novel metabolism-based therapeutic approach using a polyurea generation 4 dendrimer (PURE(G4)) surface functionalized with lactate (LA) (PURE(G4)-LA(24)), to take advantage of glucose-dependent... - Improved overall survival in an anti-PD-L1 treated cohort of newly diagnosed glioblastoma patients is associated with distinct immune, mutation, and gut microbiome features: a single arm prospective phase I/II trial Sun, 27 Apr 2025 06:00:00 -0400
This phase I/II trial aims to evaluate the efficacy of concurrent atezolizumab with radiation therapy and temozolomide (TMZ) followed by adjuvant atezolizumab and TMZ in newly diagnosed glioblastoma (GBM) patients and to identify pre-treatment correlates with outcome (N = 60). Trial number: NCT03174197. The primary outcome was overall survival (OS) whereas secondary outcomes were retrospective global-omics analyses to identify pre-treatment immune and genetic tumor features that correlated with... - Exploring the molecular mechanisms underlying intervertebral disc degeneration by analysing multiple datasets Sun, 27 Apr 2025 06:00:00 -0400
The purpose of this study was to explore the genetic characteristics and immune cell infiltration related to intervertebral disc degeneration through multidataset analysis, predict potential therapeutic drugs, and provide a theoretical basis for clinical treatment. The gene expression profile data of the GSE70362, GSE186542, and GSE245147 datasets were downloaded from the Gene Expression Omnibus (GEO) database, and the hub genes were identified through differentially expressed gene analysis,... - FBL promotes hepatocellular carcinoma tumorigenesis and progression by recruiting YY1 to enhance CAD gene expression Sun, 27 Apr 2025 06:00:00 -0400
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. Accumulating evidence suggests that epigenetic dysregulation contributes to the initiation and progression of HCC. We aimed to investigate key epigenetic regulators that contribute to tumorigenesis and progression, providing a theoretical basis for targeted therapy for HCC. We performed a comprehensive epigenetic analysis of differentially expressed genes in LIHC from the TCGA database. We identified... - Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis Sun, 27 Apr 2025 06:00:00 -0400
CONCLUSIONS: This study supported that increased HMGCR expression was associated with an increased risk of cystic kidney disease and PKD, suggesting potential benefits of statin therapy for cystic kidney disease and PKD. Further research is necessary to elucidate specific mechanisms and potential therapeutic applications of HMGCR inhibitors. - An anti-androgen resistance-related gene signature acts as a prognostic marker and increases enzalutamide efficacy via PLK1 inhibition in prostate cancer Sun, 27 Apr 2025 06:00:00 -0400
CONCLUSION: We established a novel ARRDEGs-based prognostic signature that predicts PCa progression and response to chemotherapy and targeted therapy. The integration of this signature with immune profiling and drug sensitivity analysis provides a valuable tool for precision oncology in PCa. Our findings highlight the potential of PLK1 inhibition as a therapeutic strategy to enhance enzalutamide efficacy and overcome resistance. - LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence Sun, 27 Apr 2025 06:00:00 -0400
Despite significant advances in cancer biology research and treatment, clinical outcomes for patients with liver cancer remain unsatisfactory. The biological and molecular mechanisms underlying the bidirectional signaling between tumor cells and the tumor microenvironment (TME), which promotes tumor progression in the liver, remain to be elucidated. Fibroblasts are crucial regulators of tumor progression and response to therapy; however, our understanding of their roles remains limited. Here, we... - Phialophora americana infection in a patient with a compound heterozygous CARD9 mutation Sun, 27 Apr 2025 06:00:00 -0400
Phaeohyphomycosis caused by Phialophora americana is relatively rare in clinical practice. Deficiency in the human caspase recruitment domain-containing protein 9 (CARD9) is associated with infections caused by Phialophora americana. In this case, the patient has had a decade-long history of recurrent tinea corporis and recently presented with an invasive, deep subcutaneous infection in the right axilla caused by Phialophora americana. Metagenomic next-generation sequencing (mNGS) confirmed that... - Current view on the etiopathogenesis of aplastic anemia Sun, 27 Apr 2025 06:00:00 -0400
Aplastic anemia (AA) is a rare bone marrow failure syndrome marked by hypocellular bone marrow and pancytopenia, typically without abnormal infiltration or reticulin fiber increase. It often presents as acute, severe cytopenia in young adults and can have high mortality if untreated. Recent advancements, including immunosuppressive therapy (IST) combined with eltrombopag and hematopoietic stem cell transplantation (HSCT), have improved patient outcomes. This review discusses current... - Prediction of immunotherapy targets for chronic cerebral hypoperfusion by bioinformatics method Sun, 27 Apr 2025 06:00:00 -0400
Chronic cerebral hypoperfusion (CCH) plays an important role in the occurrence and development of vascular dementia (VD). Recent studies have indicated that multiple stages of immune-inflammatory response are involved in the process of cerebral ischemia, drawing increasing attention to immune therapies for cerebral ischemia. This study aims to identify potential immune therapeutic targets for CCH using bioinformatics methods from an immunological perspective. We identified a total of 823... - SOHO State of the Art Updates and Next Questions. Atypical Chronic Myeloid Leukemia: Pathogenesis, Diagnostic Challenges, and Therapeutic Strategies Sun, 27 Apr 2025 06:00:00 -0400
Atypical chronic myeloid leukemia (aCML) is a rare and challenging clonal hematopoietic disorder within the myelodysplastic/myeloproliferative neoplasm (MDS/MPN) spectrum. Over the past two decades, substantial progress has been made in understanding the genetic mechanisms driving aCML, revealing a complex and heterogeneous mutational landscape. Key ancestral mutations, such as ASXL1 and ETNK1, have been identified, providing a foundation for the pathogenesis and for the possible emergence of... - Primary renal tubular acidosis during pregnancy, what about the perinatal prognosis? A case report and literature review Sun, 27 Apr 2025 06:00:00 -0400
Renal tubular acidosis (RTA) is a group of disorders caused by tubular defects leading to defective reabsorption of bicarbonate (HCO(3)^(-)) and/or secretion of protons (H^(+)). It is known that pregnancy can induce or worsen some forms of RTA. To date, no systematic data exist on the course of pregnancy in hereditary RTA-affected mothers, nor on the outcome of both mothers and children. A 35-year-old female patient attends her routine obstetric follow-up consultation at 32-weeks' pregnancy.... - Suppressing SPARC gene with siRNA exerts therapeutic effects and inhibits MMP-2/9 and ADAMTS1 overexpression in a murine model of ischemia/reperfusion-induced acute kidney injury Sun, 27 Apr 2025 06:00:00 -0400
Secreted protein acidic and rich in cysteine (SPARC), a collagen-binding matricellular protein, is reported to facilitate inflammation and fibrosis in various tissues including the kidneys. Ischemia/reperfusion (I/R) is a major process of acute kidney injury. To investigate whether SPARC inhibition might attenuate renal I/R injury, we injected small interfering RNA (siRNA) targeting SPARC into male BALB/c mice one day before 45 min of renal ischemia followed by 72 h of reperfusion. Serum... - Circular RNA circATM binds PARP1 to suppress Wnt/β-catenin signaling and induce cell cycle arrest in gastric cancer cells Sun, 27 Apr 2025 06:00:00 -0400
CONCLUSION: Taken together, we defined circATM as a novel gastric tumor suppressor via interacting with PARP1, which indicate that circATM may be a promising biomarker for the diagnosis and therapy of GC.
Literature Menu
- Cancer Gene Therapy
- Current Gene Therapy
- Current Molecular Medicine
- Gene Therapy
- Gene Therapy and Molecular Biology
- Gene Therapy and Regulation
- Genetic Vaccines and Therapy
- Human Gene Therapy
- Journal of Gene Medicine
- Journal of Molecular Medicine
- Molecular Therapy
- Nature Medicine
- Open Gene Therapy Journal
- Trends in Molecular Medicine
Gene Therapy News
- Cell and Gene Therapy CRO Market is on an Upward Growth Curve - openPR.com
Mon, 28 Apr 2025 14:26:4 GMT - Cell and Gene Therapy Supply Chain/Logistics Market Size, Share and Trends Analysis Report 2025-2034 - openPR.com
Mon, 28 Apr 2025 12:35:0 GMT - Synthetic promoters enhance gene therapy precision - Drug Target Review
Mon, 28 Apr 2025 10:04:5 GMT - Cell and Gene Therapy Sector Enters ‘Critical’ Period After Marks’ FDA Exit - BioSpace
Mon, 28 Apr 2025 06:08:5 GMT - Trailblazer: a gene therapy pathway to a cure for HIV - cosmosmagazine.com
Sun, 27 Apr 2025 22:30:0 GMT