News-Medical.Net Gene Therapy News
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Next generation mRNA vaccines exhibit excellent protective and therapeutic effects
Aug 16, 2022 | 07:28 amResearchers around the world have been working for years on developing vaccines against different types of cancer, but without much success. Now, Tufts School of Engineering researchers think they have found one that does work. They have devised a method of targeting cancer in mice with a vaccine that is so strong and precise, it eliminates tumors and even prevents their recurrence.
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Higher doses of CAR-T therapy achieve better survival rates for young patients with hard-to-treat B-ALL
Aug 9, 2022 | 03:09 amYoung people who received doses of tisagenlecleucel, a chimeric antigen receptor T cell (CAR-T) therapy, at the higher end of the FDA-approved dosing range had significantly better survival rates at one year compared with those who received lower doses within this range, according to research published today in Blood Advances.
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Insights into the products and services of Azenta
Aug 8, 2022 | 12:31 pmThis interview talks to Andre Kotze about the different services and products available at Azenta.
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Terminally exhausted T cells may remain competent for transcription, researchers say
Aug 8, 2022 | 07:31 amDuring a battle with cancer, T cells can become exhausted and are no longer able to function properly. The early phase of exhaustion can sometimes be reversed with immunotherapy drugs, but once T cells become too exhausted, it had been thought that this state was irreversible. However, new insights from University of Pittsburgh and UPMC researchers suggest that even the most fatigued T cells can be revived.
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Gene therapy approach delays disease onset in humanized mouse models of familial ALS
Aug 3, 2022 | 00:32 amAmyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the progressive loss of motor neurons in the brain and spinal cord responsible for voluntary movements and muscle control.
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New DNA repair vehicle used to fix a common genetic cause of hereditary kidney disease
Jul 30, 2022 | 01:01 amGenetic mutations which cause a debilitating hereditary kidney disease affecting children and young adults have been fixed in patient-derived kidney cells using a potentially game-changing DNA repair-kit. The advance developed by University of Bristol scientists is published in Nucleic Acids Research.
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Ultra-precise gene therapy technologies could edit or silence faulty genes causing fatal heart diseases
Jul 29, 2022 | 08:54 amAn injectable cure for inherited heart muscle conditions that can kill young people in the prime of their lives could be available within a few years, after an international team of researchers were announced as the winners of the British Heart Foundation's Big Beat Challenge.
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Mesoporous silica nanoparticles: Possibilities in therapeutic development
Jul 28, 2022 | 08:08 amIn this interview, News-Medical talks to Philippe Riviere, Senior Scientist at NanoComposix (now a Fortis Life Sciences company) about mesoporous silica nanoparticles and the possibilities and opportunities they provide to drug delivery, vaccine development and more.
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Scientists receive $3.9 million NIH grant to eradicate HIV from the brain
Jul 27, 2022 | 20:53 pmFinding a cure for HIV has been extremely difficult, in part because the virus hides from antiretroviral treatments in one of the hardest places to reach: the brain.
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Insights into molecular folding of AAT protein will help develop new therapies for alpha-1 antitrypsin deficiency
Jul 26, 2022 | 00:32 amIn a major new development in the quest to develop better gene therapies with which to treat a host of diseases, researchers at the University of Massachusetts Amherst and UMass Chan Medical School recently announced that they have mapped the expression and maturation of the protein alpha-1 antitrypsin (AAT) with unprecedented clarity.
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