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A virus based vaccine combined with IL12 gene therapy eradicates aggressive melanoma
Posted on: 29 May 2025, source: Nature
This study presents a novel cancer vaccine strategy using genetically engineered bacteriophages. These phages display tumor-associated peptides on their surface and were tested in a mouse melanoma model, both alone and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Both treatments significantly delayed tumor growth, and their combination had a synergistic effect, leading to complete tumor regression in 30% of cases. Tissue analysis showed increased immune activation, including higher levels of necrosis and infiltration by macrophages, CD4+, and CD8+ T cells. This is the first time a combination of three different engineered M13 phages with intratumoral IL-12 GET has been tested, demonstrating strong therapeutic potential. The results highlight the promise of nanotechnological approaches like phage-based vaccines in cancer treatment.
This study presents a novel cancer vaccine strategy using genetically engineered bacteriophages. These phages display tumor-associated peptides on their surface and were tested in a mouse melanoma model, both alone and in combination with gene electrotransfer (GET) of interleukin-12 (IL-12) plasmids. Both treatments significantly delayed tumor growth, and their combination had a synergistic effect, leading to complete tumor regression in 30% of cases. Tissue analysis showed increased immune activation, including higher levels of necrosis and infiltration by macrophages, CD4+, and CD8+ T cells. This is the first time a combination of three different engineered M13 phages with intratumoral IL-12 GET has been tested, demonstrating strong therapeutic potential. The results highlight the promise of nanotechnological approaches like phage-based vaccines in cancer treatment.