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  • Assistant Investigator - Human Gene Therapy
  • The Allen Institute for Brain Science, located in Seattle, Washington, is comprised of a multidisciplinary staff committed to understanding how the brain works and helping to unlock the mysteries of neurological diseases and disorders affecting millions worldwide. Using an open science, multi-scale, team-oriented approach, the Allen Institute focuses on accelerating foundational research, developing standards and models, and cultivating new ideas to make a broad, transformational impact on science.

    We have recently begun a gene therapy program that builds on our pioneering characterization of brain cell types to develop and test new therapeutic AAVs to treat brain disorders by targeting specific cell types. We seek an outstanding individual to lead research efforts in multiple neurodevelopmental and/or neurodegenerative disorders, working in a team environment to take tools and knowledge developed in the basic research arm of the Institute to preclinical studies aimed to advance candidate vectors towards clinical applications.

    The successful candidate will have a strong background in gene therapy-related applications in academia or industry, preferably with expertise in neurodevelopmental and neurodegeneration-related diseases. We seek an individual with a track record of both individual and team contributions in solving complex research problems, and experience in cutting edge viral vector technologies and animal model preclinical studies. This is a multidisciplinary project requiring knowledge of AAV-based gene therapy applications, modern single cell -omics methods, animal model behavioral studies, biodistribution and toxicology studies. Strong preference will be given to candidates that bring expertise in advancing candidate therapeutic vectors through IND-enabling studies.

    Reporting to the Director of the Human Cell Types Department at the Allen Institute for Brain Science, the ideal candidate is a self-motivated team player who is willing to push the boundaries of human gene therapy research through scientific leadership, individual and team contributions and continuing scholarship in this ever-changing landscape. The candidate should have management experience and will be expected to help recruit and build a team of top caliber scientists and research associates. The successful candidate will also have excellent communication skills that can represent our efforts to our stakeholders internally and in external forum.

    The Allen Institute offers exceptional working conditions, and nurtures team science in an intellectually rich and stimulating setting. We provide a highly collaborative research environment offering the opportunity to interface closely with our molecular and cell biologists, bioinformaticians, and academic and industry partners. This is a Principal Investigator position similar to an Assistant Professor in a University/Medical School setting. The successful candidate will have demonstrated research productivity and is in early stages of defining and implementing an independent research program. The candidate should have publications in relevant peer-reviewed scientific journals.

    The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences, and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

    Essential Functions

    Lead the research to solve complex AAV-based gene therapy research problems
    Lead the design of AAV-based gene therapy applications
    Regularly present data (in oral and/or written form) to the internal and external research communities.
    Lead the collaborative efforts with other scientific and management teams in data generation and analysis
    Will lead and directly participate in team recruitment activities
    Required Education and Experience

    Ph.D. and/or M.D. in neuroscience, biology, physics, engineering, or related academic or biomedical discipline; or equivalent combination of degree and experience
    5 or more years of post-PhD working experience in academia or industry in brain disease research, including gene therapy-related research
    Experience and technical knowledge of AAV-based gene therapy applications, preclinical animal model studies, and IND-enabling studies with supporting publication record
    Experience managing scientific teams
    Proven strong written and verbal communication skills
    Excellent management skills and ability to work in a group and interact closely with experimentalists and computational biologists
    Preferred Education and Experience

    Direct experience in neurodevelopmental or neurodegenerative disease gene therapy, and/or disease modeling and circuit dissection of behavior
    Proven ability to drive IND-enabling preclinical studies
    Able to work independently as well as in a collaborative high paced environment
    Experience working with outside collaborators to achieve defined objectives
    Ability to meet aggressive timelines and deliverables
    Physical Demands

    Fine motor movements in fingers/hands to operate computers and other office equipment
    Position Type/Expected Hours of Work

    This role is currently able to work remotely due to COVID-19 and our focus on employee safety. We are a Washington State employer, and remote work must be performed in Washington State. We continue to evaluate the safest options for our employees. As restrictions are lifted in relation to COVID-19, this role will return to work onsite.
    Additional Comments

    **Please note, this opportunity offers relocation assistance**
    **Please note, this opportunity offers work visa sponsorship**

    It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

    Contact Information: This email address is being protected from spambots. You need JavaScript enabled to view it.

     


  • Scientist II – AAV Gene Therapy – Therapeutic Lead
  • The mission of the Allen Institute for Brain Science is to accelerate the understanding of how the human brain works in health and disease. Using a big science approach, we generate useful public resources, drive technological and analytical advances, and discover fundamental brain properties through integration of experiments, modeling and theory.

    We are seeking a scientist to join the gene therapy program at the Allen Institute for Brain Science. This program aims to develop and test new therapeutic AAVs to treat brain disorders including severe forms of epilepsy and other neurodevelopmental diseases using a novel AAV-based cell type-specific expression system. We are seeking a scientist with a strong background in neuroscience, models of neurological diseases, and molecular and cellular biology. We are particularly interested in scientists with strong backgrounds in genetic forms of epilepsy and intellectual disability, and generating therapeutic strategies to treat those disorders.

    The scientist will lead efforts to build and validate new AAV-based therapeutics for a particular epileptic neurodevelopmental disorder. This scientist will be the intellectual lead for this disease and will be expected to become a domain expert for current state of the art in that field. They will lead therapeutic AAV design and construction, establishing cell-culture based and in vivo assays to measure a functional response to the vectors and establishing efficacy. This scientist will also lead experiments to establish vector safety and biodistribution. They will also be responsible for prompt and accurate reporting of data to the group and external collaborators. This individual must have a strong track record and be excited by the prospect of joining a team-science environment at the Allen Institute for Brain Science to help develop new gene therapies for brain diseases.

    The Allen Institute believes that team science significantly benefits from the participation of diverse voices, experiences and backgrounds. High-quality science can only be produced when it includes different perspectives. We are committed to increasing diversity across every team and encourage people from all backgrounds to apply for this role.

    Essential Functions

    Construction of AAV vectors using standard molecular techniques
    Evaluation of expression in brain using IHC, mFISH, and fluorescence microscopy
    Evaluation of biodistribution of AAV vectors
    Phenotypic evaluation of animal model(s) of human neurological diseases, possibly including EEG
    Act as expert/point person on certain disease indications
    Management of 1-2 direct reports, providing work direction and support as needed
    Rapid and transparent communication of all results
    Ability to take on complex problems and come up with novel solutions in a timeline, milestone-driven, and team-centric environment
    Provide presentations of results internally, externally, and through publications
    Coordinate with commercial partners on vector development and testing
    Lead experimental planning and analysis efforts
    Note: Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions. This description reflects management’s assignment of essential functions; it does not proscribe or restrict the tasks that may be assigned.

    Required Education and Experience

    PhD and 3 years experience in neurobiology, virology, or related fields; or equivalent combination of degree and experience
    Experience in MS Office programs and other relevant software programs (eg standard DNA sequence analysis, image analysis, etc)
    Preferred Education and Experience

    PhD and 5-7 years experience in neurobiology, virology, or related fields
    Strong experience with animal models of neurological disease
    Building, purifying, and applying AAV viruses
    Developing AAV-based gene therapies
    Biodistribution analysis of AAVs
    Electrophysiological recordings in animal models of neurological disease
    EEG in mouse models of epilepsy
    Multiplexed FISH or IHC in brain tissue
    Proficiency in brain staining and imaging using fluorescence and confocal microscopy
    Highly motivated researcher, comfortable independently solving problems and establishing new procedures and processes.
    Excellent organizational and communication skills
    Experience leading projects, designing research projects, and mentoring others
    Strong publication record
    Work Environment

    Exposure and handling of laboratory animals required
    Frequently required to sit, stand, walk, stoop, kneel or reach
    Laboratory atmosphere - possible exposure to chemical, biological, or other hazardous substances including possible exposure to BioSafety Level 2 organisms, such as recombinant viruses. This may include wearing personnel protective equipment (PPE) - including wearing respiratory protection for long periods of time
    Physical Demands

    Occasional lifting to 30 pounds
    Fine motor movements in fingers/hands to operate computers and other office equipment; lab equipment
    Position Type

    This role is currently working onsite and remotely when possible, due to COVID-19 and our focus on employee safety. We continue to evaluate the safest options for our employees
    This position is funded through a sponsored research collaboration
    Additional Comments

    **Please note, this opportunity offers relocation assistance and may offer visa sponsorship**
    It is the policy of the Allen Institute to provide equal employment opportunity (EEO) to all persons regardless of age, color, national origin, citizenship status, physical or mental disability, race, religion, creed, gender, sex, sexual orientation, gender identity and/or expression, genetic information, marital status, status with regard to public assistance, veteran status, or any other characteristic protected by federal, state or local law. In addition, the Allen Institute will provide reasonable accommodations for qualified individuals with disabilities.

    Contact Information: This email address is being protected from spambots. You need JavaScript enabled to view it.

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